Reactive Intermediates

SnapShot: Reactive Oxygen Intermediates (ROI)

Chemically reactive intermediates and pulmonary xenobiotic toxicity.

After reading this lengthy review, the reader may consider it foolhardy to attempt to summarize the data contained herein. If so, the author and the reader are in complete accord. I set out to integrate, wherever possible, pathological changes in tissues and cells as determined by light, scanning, and TEM with chemical, biochemical, molecular, biological, and genetic techniques. I am not so nai...

Reactive intermediates in cytochrome p450 catalysis.

Recently, we reported the spectroscopic and kinetic characterizations of cytochrome P450 compound I in CYP119A1, effectively closing the catalytic cycle of cytochrome P450-mediated hydroxylations. In this minireview, we focus on the developments that made this breakthrough possible. We examine the importance of enzyme purification in the quest for reactive intermediates and report the preparati...

NMR Spectroscopic Analyses of Anionic Reactive Intermediates

New reactive intermediates in organic chemistry

Physical organic chemistry (POC) and reactive intermediate chemistry (RIC) belong to the core subjects of organic chemistry. During the 1990s and 2000s both had become increasingly less fashionable, and in many countries, the mass of active researchers working in POC and RIC was in danger of becoming subcritical. Consequently, in 2003, the WhitesidesReport on the status of chemistry in Great Br...